Protein Ligand Interactions

Biomolecular interactions

All functions of living systems ranging from primitive bacteria to higher-order organisms, as well as their interactions with their environment, are realised through macromolecular interactions.

These interactions might be simple or rather complex with at least one of the partners being a biological macromolecule, usually a protein.

DIFFERENT TYPES OF INTERACTION

The interactions of proteins with other proteins, small molecules, carbohydrates, lipids or nucleic acids

Receptor-ligand interactions
Antigen-antibody interactions
Enzymatic interactions, 
enzyme-inhibitor interactions





❖ ligand binding such as that of steroid hormones to their cytoplasmic or nuclear receptors or the binding of secreted peptide ligands to transmembrane receptors might activate a receptor molecule, which induces a cellular response




Reaction kinetics

⚫ protein-ligand interaction include the concentrations of the partners, the binding affinity, and the rate constants of association and dissociation

Let us consider the following interaction:

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